Hands down, the best how-to blog being written today is Lifehacker.
A how-to video blog featuring video tutorials that discuss web development and technology tips, internet marketing strategies, and legal issues for Internet content producers and marketers.
"Answers and advice from real people." That's the tag line of Ask Deb, which has the very simple goal of answering other people's questions.

art blogging business cars design education entertainment fashion finance fitness food football gadgets gardening gossip health humor internet internet marketing investing jewelry life lifestyle marketing money music news parenting personal personal finance photography politics real estate relationships reviews science search seo shopping soccer software sports technology travel video web 2.0 weight loss women wordpress writing